IL PORTALE per la RICERCA dei DIPARTIMENTI

Tintori C, Botta M (2012) "'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells."

Stefania Butini, Sandra Gemma, Giuseppe Campiani (2012) "A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs"

Dreassi E., Botta M. (2012) "A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation"

Petricci E., Taddei M. (2012) "A general approach to substituted benzimidazoles and benzoxazoles via heterogeneous palladium catalyzed hydrogen transfer with primary amines"

Corelli F, Mugnaini C (2012) "A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury"

Botta M (2012) "ATP-competitive inhibitors of mTOR: An update"

F. MANETTI, Taddei M (2012) "Acylthiourea, Acylurea and Acylguanidine Derivatives with potent Hedgehog inhibiting Activity"

Millucci L., Braconi D., Ghezzi L., Laschi M., Orlandini M., Santucci A. (2012) "Alkaptonuria is a novel human secondary amyloidogenic disease"

Giorgi G. (2012) "An Original Route to Newly-Functionalized Indoles and Carbazoles Starting from the Ring-Opening of Nitrothiophenes"

Baldari CT, Orlandini M. (2012) "An apical actin-rich domain drives the establishment of cell polarity during cell adhesion."

Botta M. (2012) "An update on dual Src/Abl inhibitors."

Dreassi E., Corbini G. (2012) "Analysing the interaction between cytotoxic chemotherapy drugs and medical devices used for preparation and administration"

Maurizio Botta (2012) "Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition"

S. A. Loiselle (2012) "Basin-scale Control on the Phytoplankton Biomass in Lake Victoria, Africa"

SINICROPI A. (2012) "Bathochromic shift in Green Fluorescent Protein: A puzzle for QM/MM approaches"

Braconi D., Laschi M., Millucci L., Santucci A. (2012) "Biochemical and proteomic characterization of alkaptonuric chondrocytes"

Casolaro M. (2012) "Biohydrogels with magnetic NP as crosslinker: Characteristics and potential use for controlled antitumor drug-delivery"

Fedi S., Fabrizi de Biani F. (2012) "Cage rearrangements in dodecanuclear Co-Pt dicarbido clusters promoted by redox reactions"

Gaggelli E, Valensin G (2012) "Capreomycin - A polypeptide antitubercular antibiotic with unusual binding properties toward copper(II)"

Giorgi G. (2012) "Characterization of gas phase aggregates of bis(2-ethylhexyl)-sulfosuccinate (AOT) and divalent metal ions: elimination of radical species in the decomposition pathways of even-electron [AOTMIICl2]– anions"

Mugnaini C., Tafi A., Brogi S., Corelli F. (2012) "Characterization of methyl 2-(1-adamantanecarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate (COR627) and methyl 2-(cyclohexanecarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate (COR628), two novel positive allosteric modulators of the GABAB receptor."

Steven Loiselle, Claudio Rossi (2012) "Chemical and optical phototransformation of dissolved organic matter"

Gemma Leone, Stefania Lamponi, Agnese Magnani (2012) "Combination of static time of flight secondary ion mass spectrometry and infrared reflection–adsorption spectroscopy for the characterisation of a four steps built-up carbohydrate array"

Mugnaini C., Corelli F. (2012) "Comparison of the effect of the positive allosteric modulator of the GABAb receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats"

Daniela Valensin (2012) "Coordination of Ni2+ and Cu2+ to metal ion binding domains of E. coli SlyD protein"

Mangani S (2012) "Copper(I)-alkyl sulfide and -cysteine tri-nuclear clusters as models for metallo proteins: a structural density functional analysis."

Valensin D. (2012) "Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)"

Mugnaini C., Tafi A., Brogi S., Corelli F (2012) "Design, Synthesis, and Pharmacological Characterization of Indole-3-ylacetamides, Indole-3-yloxoacetamides, and Indole-3-ylcarboxamides: Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists"

Basosi R. (2012) "Destabilization of lipid membranes by a Peptide derived from Glycoprotein gp36 of feline immunodeficiency virus: a combined molecular dynamics/experimental study"

Brindisi M (2012) "Developing ß-secretase inhibitors for treatment of Alzheimer’s disease"

Tintori C, Botta M (2012) "Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors."

Stefania Butini, Margherita Brindisi, Sandra Gemma, Giuseppe Campiani (2012) "Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases"

Tintori C, Botta M. (2012) "Discovery of small molecule HIV-1 integrase dimerization inhibitors."

Manetti F, Botta M. (2012) "Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors"

Cini E, Taddei M. (2012) "Downregulation of hypoxia-related responses by novel antitumor histone deacetylase inhibitors in MDAMB231 breast cancer cells."

Massimo Olivucci (2012) "Dynamic Electron Correlation Effects on the Ground State Potential Energy Surface of a Retinal Chromophore Model"

C. Bonechi, C Rossi (2012) "Effect of quercetin, rutin, naringenin and epicatechin on lipid peroxidation induced in human sperm."

A. Atrei (2012) "Effects of epitaxial films of nanometric thickness on the X-ray photoelectron diffraction intensities from substrates"

Niccolai N (2012) "Efficacy and toxicity of the antimicrobial peptide M33 produced with different counter-ions."

Travagli V. (2012) "Emerging topics in cutaneous wound repair"

Basosi R. (2012) "Enzymatic decolorization of spent textile dyeing baths composed by mixtures of ynthetic dyes and additives"

A. Atrei (2012) "Epitaxial growth of TiO2 films with the rutile(110) structure on Ag(100)"

Andrea Cappelli, Marco Paolino, Germano Giuliani (2012) "Evaluation of thermoresponsive properties and biocompatibility of polybenzofulvene aggregates for leuprolide delivery"

Maurizio Taddei (2012) "From Alcohols to Indoles: A Tandem Ru Catalyzed Hydrogen-Transfer Fischer Indole Synthesis"

Marisanna Centini (2012) "GC-MS profiling of the phytochemical constituents of the oleoresin from Copaifera langsdorffii Desf. and a preliminary in vivo evaluation of its antipsoriatic effect."

Giorgi G. (2012) "Gas-phase doubly charged complexes of cyclic peptides with copper in +1, +2 and +3 formal oxidation states: formation, structures and electron capture dissociation"

Spiga O., Niccolai N. (2012) "Genetic differentiation between Cinta Senese and commercial pig breeds using microsatellite"

Maurizio Botta (2012) "HIV-1 Integrase: Mechanism and Inhibitor Design Edited by Nouri Neamati."

F. MANETTI (2012) "HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment"

Laschi M., Braconi D., Millucci L., Ghezzi L., Santucci A. (2012) "Homogentisate 1,2 dioxygenase is expressed in human osteoarticular cells: implications in alkaptonuria."

S. LAMPONI, G. LEONE, A. MAGNANI (2012) "IN VITRO BIOCOMPATIBILITY OF NEW PVA-BASED HYDROGELS AS VITREOUS BODY SUBSTITUTES"

Tintori C., Botta M. (2012) "Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling."

Trabalzini L (2012) "Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1."

Maurizio Anzini (2012) "Improving the Solubility of a New Class of Antiinflammatory Pharmacodynamic Hybrids, that Release Nitric Oxide and Inhibit Cycloxygenase-2 Isoenzyme"

Anzini M. (2012) "In Vitro Effects of VA441, a New Selective Cyclooxygenase-2 Inhibitor, on Human Osteoarthritic Chondrocytes exposed to IL-1ß."

Baratto M.C., Basosi R. (2012) "Influence of pH on the speciation of copper(II) in reactions with the green tea polyphenols, epigallocatechin gallate and gallic acid"

Spinelli D., Basosi R. (2012) "Integrated environmental assessment of sunflower oil production"

Giorgi G. (2012) "Investigation on the reactivity of isoxazol-5-ones towards 1,2-diaza-1,3-dienes: new entry to variously substituted (imidazol-2-yl)acetate and 1,3-oxazin-6-one derivatives"

Mugnaini C., Brizzi A., Corelli F. (2012) "Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 6. Synthesis and Pharmacological Evaluation of 7-Substituted 4-Quinolone-3-carboxamide Derivatives as High Affinity Ligands for Cannabinoid Receptors"

Mugnaini C., Tafi A., Corelli F. (2012) "Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach."

F. MANETTI (2012) "LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators"

Fusi S., Olivucci M. (2012) "Mechanistic Origin of the Vibrational Coherence Accompanying the Photoreaction of Biomimetic Molecular Switches"

Claudia Bonechi, Claudio Rossi (2012) "Metabolic response to exogenous ethanol in yeast: An in-vivo statistical total correlation NMR-spectroscopy approach"

Valensin D. (2012) "Metal compounds as inhibitors of ß-amyloid aggregation. Perspectives for an innovative metallotherapeutics on Alzheimer's disease"

Claudia Bonechi (2012) "Methyl carnosate, an antibacterial diterpene isolated from Salvia officinalis leaves"

Sandra Gemma, Margherita Brindisi, Simone Brogi, Stefania Lamponi, Luisa Savini, Giuseppe Campiani, Stefania Butini (2012) "Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents"

F. MANETTI, Botta M (2012) "MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212"

L. TRABALZINI (2012) "Molecular Crosstalk between Integrins and Cadherins: do Reactive Oxygen Species Set the Talk?"

Casolaro M. (2012) "Multiple stimuli-responsive hydrogels for metal-based drug therapy"

Niccolai N. (2012) "NMR Studies on Structure and Dynamics of the Monomeric Derivative of BS-RNase: New Insights for 3D Domain Swapping."

Valensin D., Gaggelli E., Valensin G. (2012) "NMR metabolomic investigation of astrocytes interacted with Aß42 or its complexes with either copper(II) or zinc(II)"

Gemma Leone, Stefania Lamponi, Agnese Magnani (2012) "New hyaluroran derivative with prolonged half-life for ophthalmogical formulation"

CENTINI M, SEGA A. (2012) "New multifunctional surfactants from natural phenolic acids."

Botta M (2012) "New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization."

Germano Giuliani, Andrea Cappelli, Maurizio Anzini (2012) "New red-shifted coelenterazine analogues with an extended electronic conjugation"

Fedi S., Fabrizi de Biani F. (2012) "Nickel poly-acetylide carbonyl clusters: structural features, bonding and electrochemical behaviour"

Loiselle Steven Arthur (2012) "Optical approaches to examining the dynamics of dissolved organic carbon in optically complex inland waters"

Sandra Gemma, Simone Brogi, Luisa Savini, Stefania Lamponi, Giuseppe Campiani, Stefania Butini (2012) "Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling"

Massimo Olivucci (2012) "Origin of Fluorescence in 11-cisLocked Bovine Rhodopsin"

B. Marzocchi (2012) "Perinatal outcome and placental histological characteristics: a single-center study."

Stefania Fusi, Massimo Olivucci (2012) "Photoisomerization and Relaxation Dynamics of a Structurally Modified Biomimetic Photoswitch"

Santucci A (2012) "Polysorbate 80 and Helicobacter pylori: a microbiological and ultrastructural study"

Braconi D, Santucci A. (2012) "Post-genomics of bone metabolic dysfunctions and neoplasias."

Gianluca Giorgi (2012) "Powerful Approach to Heterocyclic Skeletal Diversity by Sequential Three-Component Reaction of Amines, Isothiocyanates, and 1,2-Diaza-1,3-dienes"

Millucci L., Ghezzi L., Braconi D., Santucci A. (2012) "Prevalence of isolated atrial amyloidosis in young patients affected by congestive heart failure"

Massimo Olivucci (2012) "Quantum chemical modeling of rhodopsin mutants displaying switchable colors"

Sandra Gemma, Margherita Brindisi, Simone Brogi, Luisa Savini, Stefania Butini, Giuseppe Campiani (2012) "Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1"

Trabalzini L (2012) "Reactive oxygen species: friends and foes of signal transduction."

F. MANETTI (2012) "Recent Findings Confirm LIM Domain Kinases as Emerging Target Candidates for Cancer Therapy"

Daniela Braconi, Lia Millucci, Annalisa Santucci (2012) "Rubus ulmifolius Leaf Extract Inhibits Proliferation of Murine Myeloma Cells"

Travagli V (2012) "Selective ozone concentrations may reduce the ischemic damage after a stroke."

Marco Paolino, Andrea Cappelli (2012) "Self-assembly of poly(propylene imine) glycodendrimers: role of aromatic interactions in the formation of necklace- and donut-like nanostructures"

Valensin G (2012) "Specific poly-histidyl and poly-cysteil protein sites involved in Ni(2+) homeostasis in Helicobacter pylori. Impact of Bi(3+) ions on Ni(2+) binding to proteins. Structural and thermodynamic aspects"

Cini E (2012) "Stereoarrays with an All-Carbon Quaternary Center: Diasteroselective Desymmetrization of Prochiral Malonaldehydes"

Taddei M. (2012) "Stereoselective multicomponent assembly of enantiopure oxazolopiperidines and –azepines"

Mario Casolaro, Stefania Lamponi (2012) "Stimuli-responsive hydrogels for controlled pilocarpine ocular delivery"

S. Mangani, C. Pozzi (2012) "Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes"

D. VALENSIN (2012) "Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases"

Botta M (2012) "Studies on the acylation of 4-(2-aminoethylthio)-7-nitrobenzofurazan: The role of bases in promoting the formation of fluorescent S-acyl derivatives through S-N Smiles rearrangement."

Braconi D., Santucci A., Travagli V. (2012) "Supportive use of cyclodextrins as decontamination agents for herbicides"

Giorgi G. (2012) "Surfactant Self-Assembling in the Gas Phase: Bis(2-ethylhexyl)sulfosuccinate-Divalent Metal Ion Anionic Aggregates"

Andrea Cappelli, Marco Paolino, Germano Giuliani, Alessandro Donati, Gianluca Giorgi (2012) "Synthesis and characterization of charge-transporting p-stacked polybenzofulvene derivatives"

E. Cini, M. Taddei (2012) "Synthesis of Enantiopure 7-Substituted Azepane-2-carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics"

Stefania Lamponi, Agnese Magnani (2012) "Synthesis of esters of androgens with unsaturated fatty acids for androgen requiring therapy"

Dreassi E, Botta M. (2012) "Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors."

Maccari G., Botta M. (2012) "Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1."

Fedi S., Fabrizi de Biani F., Laschi F. (2012) "Synthesis, reactivity, electrochemical behavior, and crystal structure of a family of multivalent metal carbido–carbonyl clusters based on the Rh10(C)2Au4–6 framework"

Fedi S., Fabrizi de Biani F. (2012) "Synthesis, structure, and electrochemistry of the Ni–Au carbonyl cluster [Ni12Au(CO)24]3–and its relation to [Ni32Au6(CO)44]6–"

Massimo Olivucci (2012) "The Molecular Mechanism of Dark Noise in Rod Photoreceptors"

Mugnaini C., Corelli F. (2012) "The bioisosteric concept applied to cannabinoid ligands"

L. TRABALZINI (2012) "The interplay between ROS and Ras GTPases: physiological and pathological implications."

Bernini C., Pogni R., Basosi R., Sinicropi A. (2012) "The nature of tryptophan radicals involved in the long-range electron transfer of lignin peroxidase and lignin peroxidase-like systems: insights from quantum mechanical/molecular mechanics simulations"

Travagli V. (2012) "The reliable and effective oxygen-ozone therapy at a cross-roads with ozonated saline infusion and ozone rectal insufflation."

Pozzi C, Mangani S (2012) "The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism."

Spiga O., Botta M., Niccolai N. (2012) "The use of a ditopic Gd(III) paramagnetic probe for investigating a-bungarotoxin surface accessibility."

Valensin D. (2012) "Thermodynamic and spectroscopic investigation on the role of Met residues in Cu II binding to the non-octarepeat site of the human prion protein"

Stefania Fusi, Massimo Olivucci (2012) "Toward a Stable a-Cycloalkyl Amino Acid with a Photoswitchable Cationic Side Chain"

Botta M. (2012) "Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein."

Claudia Bonechi, Stefania Lamponi, Claudio Rossi (2012) "Using Liposomes as Carriers for Polyphenolic Compounds: The Case of Trans-Resveratrol"

Botta M (2012) "Will Integrase Inhibitors be Used as Microbicides?"

Casolaro M. (2012) "X-ray Structure and Computational Study for N-acryloyl-L-valine, a Versatile Monomer for Preparing Smart Drug Delivery Carriers"

ORLANDINI M, F. GALVAGNI (2012) "c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1"

Manetti F., Botta M. (2012) "Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach"

D. Spinelli, M.C. Baratto, R. Basosi, R. Pogni (2012) "Synthesis of textile dyes by laccase biotransformations"