IL PORTALE per la RICERCA dei DIPARTIMENTI

S. Pellegrino, A. Contini, F. Clerici, M.L. Gelmi (2012) "1H-Azepine-4-amino-4-carboxylic Acid: A New a,a-Disubstituted Ornithine Analogue Capable of Inducing Helix Conformations in Short Ala-Aib Pentapeptides"

C. Dallanoce, C. Matera, M. De Amici, C. De Micheli (2012) "A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake"

F. Cilurzo, C.G.M. Gennari, P. Minghetti (2012) "ADHESIVE PROPERTIES: A CRITICAL ISSUE IN TRANSDERMAL PATCH DEVELOPMENT"

F. Selmin (2012) "Accelerated polymer biodegradation of risperidone poly(d, l-lactide-co-glycolide) microspheres"

L. Fumagalli, M. Pallavicini, G. Chiodini, C. Bolchi, E. Valoti (2012) "Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective a1B-adrenoceptor antagonist"

G. Abbiati, E. Rossi (2012) "An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines"

L. Tamborini, A. Pinto, P. Conti (2012) "An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor"

V. Gambaro, P. Minghetti, L. Dell’Acqua, A. Casiraghi, G. Roda (2012) "Analysis of fluid extracts obtained with Papaver rhoeas petals contaminated with Papaver bracteatum petals"

A. Pancotti, S. Romeo (2012) "Antiplasmodial activities of 4-aminoquinoline–statine compounds"

N. Gaggero (2012) "BINOL derived C2-symmetric bis-sulfinates as efficient sulfinyl transfer agents in the synthesis of tert-butyl sulfoxides"

S. Villa, F. Meneghetti, A. Pedretti, D. Barlocco, A. Gelain (2012) "Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors"

R. Gandolfi (2012) "Chemoenzymatic deacylation of ramoplanin"

S. Pellegrino, M.L. Gelmi (2012) "Chemotactic effect of prorenin on human aortic smooth muscle cells : a novel function of the (pro)renin receptor"

G. Vistoli (2012) "Chiral mercaptoacetamides display enantioselective inhibition of histone deacetylase 6 and exhibit neuroprotection in cortical neuron models of oxidative stress"

A. Contini, E. Erba (2012) "Click-chemistry approach to azacycloalkene monosulfonyl diamines: synthesis and computational analysis of the reaction mechanism"

M. Cerea, A. Gazzaniga (2012) "Comparison of the In Vivo Pharmacokinetics and In Vitro Dissolution of Raltegravir in HIV Patients Receiving the Drug by Swallowing or by Chewing"

S. Villa, F. Meneghetti, A. Gelain (2012) "Complete Characterization of the 3D Properties of the CCR5 Antagonist Vicriviroc through DFT Calculations, NMR Spectroscopy, and X-ray Analysis"

C. Annoni, M.L. Gelmi (2012) "Construction of ratiometric fluorescent sensors by ribonucleopeptides"

M. Orioli, G. Aldini (2012) "D-carnosine-octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation"

A. Contini (2012) "Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity"

D. Barlocco (2012) "Designed multiple ligands: basic research vs clinical outcomes"

V. Gambaro, L.S.M. Dell’Acqua, G. Roda (2012) "Determination of the active principles of Catha Edulis : quali–quantitative analysis of cathinone, cathine, and phenylpropanolamine"

S. Pellegrino, M.L. Gelmi (2012) "Diastereoselective protocols for the synthesis of 2,3 trans- and 2,3 ci6-methoxy-morpholine-2-carboxylic acid derivatives"

V. Pirovano, G. Abbiati, M. Dell'Acqua, E. Rossi (2012) "Diels–Alder Reactions of 2-Vinylindoles with Cyclic Dienophiles: Synthesis of [c]-Annulated Tetrahydrocarbazoles"

A. Sparatore (2012) "Dithiolethiones Inhibit NF-¿B Activity via Covalent Modification in Human Estrogen Receptor-Negative Breast Cancer"

A. Sparatore (2012) "Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice"

R. Gandolfi (2012) "Enantioselective reduction and deracemisation using the non-conventional yeast Pichia glucozyma in water-organic solvent biphasic systems : preparation of (S)-1,2-diaryl-2-hydroxyethanones (benzoins)"

I. Rimoldi, G. Facchetti, E. Cesarotti, M. Pellizzoni, M. Fusè, D.S. Zerla (2012) "Enantioselective transfer hydrogenation of aryl ketones: synthesis and 2D-NMR characterization of new 8-amino-5,6,7,8-tetrahydroquinoline Ru(II)-complexes"

A. Pinto, P. Conti (2012) "Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds"

S. Pellegrino, C. Annoni, A. Contini, F. Clerici, M.L. Gelmi (2012) "Expedient chemical synthesis of 75mer DNA binding domain of MafA : an insight on its binding to insulin enhancer"

C. Bolchi, M. Pallavicini, L. Fumagalli, E. Valoti (2012) "From carnitinamide to 5-aminomethyl-2-oxazolidinones"

E. Valoti, M. Pallavicini (2012) "From pregabalin to rac-3-cyano-5-methylhexanoic acid: an easy conversion which valorizes waste pregabalin enantiomer"

A. Sparatore (2012) "Glutamate oxidative injury to RGC-5 cells in culture is necrostatin sensitive and blunted by a hydrogen sulfide (H(2)S)-releasing derivative of aspirin (ACS14)"

A. Sparatore (2012) "H(2)S-Releasing Aspirin Protects against Aspirin-Induced Gastric Injury via Reducing Oxidative Stress"

A. Arnoldi (2012) "HPLC-Chip-Multiple Reaction Monitoring (MRM) method for the label-free absolute quantification of ¿-conglutin in lupin: Proteotypic peptides and standard addition method"

P. Minghetti, F. Selmin (2012) "How to Meet Legitimate Expectations of Patients when Authorized Medicinal Products are not Available"

A. Altomare, M. Carini, G. Aldini (2012) "Human serum albumin cysteinylation is increased in end stage renal disease patients and reduced by hemodialysis : mass spectrometry studies"

A. Ruffoni, M.L. Gelmi, S. Pellegrino, F. Clerici (2012) "Hydroarylation of substituted norbornene amino acids: studies on long-range stereo-electronic effects on the regioselectivity of the addition"

A. Sparatore (2012) "Hydrogen Sulfide-Releasing Aspirin Derivative ACS14 Exerts Strong Antithrombotic Effects In Vitro and In Vivo"

A. Sparatore (2012) "Hydrogen sulfide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo"

A. Arnoldi (2012) "Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals"

E. Valoti, L. Dell’Acqua, M. Pallavicini, G. Roda, C. Rusconi, V. Gambaro (2012) "Identification of 1-butyl-3-(1-(4-methyl)naphtoyl)indole detected for the first time in ‘‘herbal high’’ products on the Italian market"

L. Zema, G. Loreti, A. Melocchi, A. Maroni, A. Gazzaniga (2012) "Injection Molding and its application to drug delivery"

A. Mazzolari, G. Vistoli (2012) "Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to a4ß2-Nicotinic Acetylcholine Receptors : An Integrated Approach to Behaviorally Active Nicotinic Ligands"

G. Grazioso, C. De Micheli (2012) "Investigating the Mechanism of Substrate Uptake and Release in the Glutamate Transporter Homologue GltPh through Metadynamics Simulations"

Fico G (2012) "Investigation of the flavonoid composition of Aconitum angustifolium Bernh. flowers and leaves"

C. De Micheli, G. Roda (2012) "Investigation on the chemoenzymatic synthesis of threo- and erythro-ß-hydroxy-l-glutamic acid derivatives"

P. Conti, A. Pinto, L. Tamborini (2012) "Ligand-exchange enantioresolution of dihydroisoxazole amino acid derivatives acting as glutamatergic modulators"

G. Aldini (2012) "Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans"

A. Arnoldi (2012) "Mechanical and thermal processing effects on protein integrity and peptide fingerprint of pea protein isolate"

G. Grazioso, C. De Micheli (2012) "Mechanism of falcipain-2 inhibition by a,ß-unsaturated benzo[1,4]diazepin-2-one methyl ester"

Ettari R (2012) "Mechanism of falcipain-2 inhibition by a,ß-unsaturated benzo[1,4]diazepin-2-one methyl ester"

A. Pinto, C. De Micheli (2012) "Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally-constrained glutamate analog (+)-HIP-B"

A. Contini, M.L. Gelmi (2012) "Molecular Dynamics and Tubulin Polymerization Kinetics Study on 1,14-Heterofused Taxanes: Evidences of Stabilization of the Tubulin Head-to-Tail Dimer-Dimer Interaction"

G. Aldini, G. Vistoli (2012) "Molecular Recognition of T:G Mismatched Base Pairs in DNA as Studied by Electrospray Ionization Mass Spectrometry"

A. Contini, E. Erba, S. Pellegrino (2012) "Multicomponent Synthesis of Pentyl-Sulfonyl Amidines via Diazoalkane"

A. Pinto, P. Conti, L. Tamborini (2012) "One-pot chemoenzymatic synthesis of aldoximes from primary alcohols in water"

L. Zema, L. Palugan, A. Gazzaniga (2012) "Optimisation and scale-up of a highly-loaded 5-ASA multi-particulate dosage form using a factorial approach"

A. Maroni, L. Zema, M. D. Del Curto, A. Foppoli, A. Gazzaniga (2012) "Oral colon delivery of insulin with the aid of functional adjuvants"

A. Sparatore (2012) "Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity"

M. Orioli, G. Aldini (2012) "Oxidative damage in human gingival fibroblasts exposed to cigarette smoke"

E. Beccalli (2012) "Palladium-catalyzed doubly C-H or N-H functionalization of unactivated indole derivatives with arenes and alkenes"

G. Beretta (2012) "Parthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-a and NF-¿B Nuclear Translocation in BV-2 Microglia"

E.M. Beccalli (2012) "Pd(II)/CuX2/Solvent Combination for Selective Intramolecular Domino Reactions of Indole Carboxylic Acid Allylamides. An Unprecedented Arylation/Esterification Sequence"

F. Cilurzo, F. Selmin, C.G.M. Gennari, P. Minghetti (2012) "Physical stability of three dimensional scaffolds from silk fibroin/PEG composite biomaterials"

G. Vistoli, A. Pedretti, L. Fumagalli, C. Bolchi, M. Pallavicini, E. Valoti (2012) "Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis"

D. Garzon, G. Vistoli, M. Carini, G. Aldini (2012) "Protein haptenation by amoxicillin : high resolution mass spectrometry analysis and identification of target proteins in serum"

C. La Rosa (2012) "Quinoline fused heterocycles from intramolecular cycloaddition reactions"

A. Pedretti, G. Vistoli (2012) "Reactions and enzymes in the metabolism of drugs and other xenobiotics"

F. Selmin, F. Cilurzo, S. Franzè, P. Minghetti (2012) "Regenerated keratin membrane to match the in vitro drug diffusion through human epidermis"

E. Pini (2012) "Rhodoxanthin as a characteristic keto-carotenoid of manakins (Pipridae)"

G. Beretta (2012) "Simple and rapid simultaneous profiling of minor components of honey by size exclusion chromatography (SEC) coupled to ultraviolet diode array detection (UV-DAD), combined with chemometric methods"

C. Lammi (2012) "Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site"

A. Ruffoni, S. Pellegrino, M.L. Gelmi, F. Clerici (2012) "Sulfanyl-methylene-5(4H)-oxazolones and ß-sulfanyl-a-nitroacrylates as appealing dienophiles for the synthesis of conformationally constrained cysteine analogues"

L. Tamborini, A. Pinto, C. De Micheli, P. Conti (2012) "Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis"

R. Ettari, G. Grazioso (2012) "Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors"

A. Barteselli, A. Sparatore (2012) "Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline"

C. Dallanoce, C. Matera, M. De Amici, C. De Micheli (2012) "Synthesis and binding affinity at a4ß2 and a7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system"

C. Rusconi, S. Romeo, A. Sparatore (2012) "Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline"

G. Grazioso (2012) "Synthesis and molecular modeling of novel dihydroxycyclopentane-carbonitrile nor-nucleosides by bromonitrile oxide 1,3-dipolar cycloaddition"

G. Abbiati, M. Dell'Acqua, V. Pirovano, E. Rossi (2012) "Synthesis of two unnatural oxygenated aaptaminoids"

F. Meneghetti (2012) "Synthesis, benzodiazepine receptor binding and molecular modelling of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives"

G. Beretta (2012) "Synthesis, characterization, DFT studies and catalytic activities of manganese(II) complex with 1,4-bis(2,2':6,2''-terpyridin-4'-yl) benzene"

A. Casiraghi, F. Cilurzo, C.G.M. Gennari, P. Minghetti (2012) "The Influence of the Polar Head and the Hydrophobic Chain on the Skin Penetration Enhancement Effect of Poly(Ethylene Glycol) Derivatives"

C. Dallanoce, C. Matera, M. De Amici (2012) "The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling"

C. Dallanoce, C. Matera, M. De Amici, C. De Micheli (2012) "The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at a4ß2 and a7 neuronal nicotinic acetylcholine receptors"

S. Villa, D. Masciocchi, A. Gelain, F. Meneghetti (2012) "The influence of the substitution pattern on the molecular conformation of ureido 1,2,5-oxadiazoles, related to STAT3 inhibitors: chemical behavior and structural investigation"

P. Minghetti, P. Rocco, F. Cilurzo (2012) "The regulatory framework of biosimilars in the European Union"

F. Cilurzo, G. Vistoli, C.G.M. Gennari, F. Selmin, S. Franzè, P. Minghetti (2012) "The role of the conformational profile of polysaccharides on skin penetration : the case of hyaluronan and sulfates thereof"

C. Matera (2012) "Total Syntheses of Anominine and Tubingensin A"

G. Vistoli, M. Carini, G. Aldini (2012) "Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs"

F. Meneghetti (2012) "Ugi 4-CR/Pictet–Spengler reaction as a short route to tryptophan-derived peptidomimetics"

G. Facchetti, E. Cesarotti, M. Pellizzoni, D. Zerla, I. Rimoldi (2012) "“In situ” Activation of Racemic RuII Complexes: Separation of trans and cis Species and Their Application in Asymmetric Reduction"

A. Arnoldi (2012) "A HPLC method for the evaluation of the ACE inhibitory activity of plant proteins hydrolysates"

M. Cerea, M.D. Del Curto, A. Foppoli, A. Maroni, A. Gazzaniga (2012) "Design and Preparation of Zero-Order Prolonged Release Systems Based on Hydrophilic Polymers Obtained with a Non-Uniform Drug Distribution"

A. Arnoldi (2012) "Evaluation of quinolizidine alkaloids in four wild Mexican lupin species"

A. Maroni, M.D. Del Curto, L. Palugan, G. Loreti, A. Melocchi, A. Gazzaniga (2012) "In vitro and in vivo evaluation of an erodible multiple-unit delivery system for oral pulsatile release"

L. Zema, G. Loreti, A. Melocchi, M. Cerea, E. Macchi, A. Gazzaniga (2012) "Injection molded gastroresistant capsular containers"

A. Gelain, D. Masciocchi, S. Villa, S. Dell’Orto, F. Meneghetti, A. Pedretti, D. Barlocco (2012) "Merged structures as new STAT3 inhibitors : the chimera compounds"

P. Gagni, A. Arnoldi (2012) "Molecular modeling and docking of food-derived Angiotensin I-converting enzyme inhibiting peptides"

A. Casiraghi, U.M. Musazzi, P. Minghetti, L. Montanari (2012) "Preparazioni semisolide contenenti propranololo : studio formulativo e valutazione della permeabilità cutanea in vitro"

E. Macchi, L. Zema, A. Gazzaniga (2012) "Release performance of injection-molded HPC-based capsules filled with different formulations of a model drug"

A. Arnoldi (2012) "The genus Lupinus is an efficient source of functional ingredients with low environmental impact"